Testicular Cancer Update

The advances seen in the treatment of testicular cancer are among the great achievements in modern medicine. These advances were made possible by the collaborative efforts of cancer researchers around the world. Investigators have been able to address many questions regarding the treatment of patients with disease limited to the testis, those with metastasis to the retroperitoneum only, and those with advanced metastatic disease. Questions answered include the chemotherapeutic agents to be used and in what combinations, the proper intensity of treatment and appropriate dosing, the optimal number of cycles of chemotherapy according to validated risk stratification, appropriate surgical approaches that preserve sexual function, the treatment of relapsed disease, what supportive care measures to take, and survivorship issues following treatment of testicular cancer. Today, cure is achievable in 95% of all patients with testicular cancer and 80% of those who have metastatic disease. Despite remarkable results with frontline and salvage combination chemotherapy, metastatic testicular cancer remains incurable in approximately 10% of patients, and novel treatment approaches are warranted. This review highlights past and recent discoveries in the treatment of patients with testicular cancer

The asymptotic S‐matrix, mass‐shell anomalies and observables

Asymptotic S‐matrix techniques are applied to the identification of a Standard Model background to polarized deep‐inelastic scattering experiments at HERA in search of Right‐handed Charged Currents. It is also pointed out that the Asymptotic S‐matrix produces finite observables free of Mass‐Shell Anomalies.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87409/2/297_1.pd

Entanglement and Nonunitary Evolution

We consider a collapsing relativistic spherical shell for a free quantum field. Once the center of the wavefunction of the shell passes a certain radius R, the degrees of freedom inside R are traced over. We show that an observer outside this region will determine that the evolution of the system is nonunitary. We argue that this phenomenon is generic to entangled systems, and discuss a possible relation to black hole physics.Comment: 14 pages, 1 figure; Added a clarification regarding the relation with black hole physic

Primary Teratoma of the Lesser Sac: Lesser Sac Teratoma

Germ cell tumors predominantly involve the gonads but may rarely be found outside of the gonads, primarily in midline structures. We describe the case of a 27-year-old male with an asymptomatic 8 cm teratoma located within the lesser sac of his omentum. This is the fourth case of a teratoma located within the lesser sac of the omentum, which provides the opportunity to make some comparisons. Finally, we discuss some of the etiologic theories behind extragonadal germ cell tumors and how they relate to teratomas in the lesser sac

Instantons of Type IIB Supergravity in Ten Dimensions

A family of SO(10) symmetric instanton solutions in Type IIB supergravity is developed. The instanton of least action is a candidate for the low-energy, semiclassical approximation to the {D=--1} brane. Unlike a previously published solution,[GGP] this admits an interpretation as a tunneling amplitude between perturbatively degenerate asymptotic states, but with action twice that found previously. A number of associated issues are discussed such as the relation between the magnetic and electric pictures, an inversion symmetry of the dilaton and the metric, the $R\times S^9$ topology of the background, and some properties of the solution in an "instanton frame" corresponding to a Lagrangian in which the dilaton's kinetic energy vanishes.Comment: 15 pages, no figures; Version 2 has revised sections IV and V. Earlier equations are essentially unchanged, but interpretation changed, on advice of counse

Vacuum Ambiguity in de Sitter Space at Strong Coupling

It is well known that in the weak coupling regime, quantum field theories in de Sitter space do not have a unique vacuum, but a class of vacua parametrized by a complex parameter $\alpha$, i.e., the so-called $\alpha$-vacua. In this article, using gauge/gravity duality, we calculate the symmetric two-point function of strongly coupled ${\cal N}=4$ supersymmetric Yang-Mills theory on $dS_3$. We find that there is a class of de Sitter invariant vacua, parametrized by a set of complex parameters $\{\alpha_{\nu}\}$.Comment: 17 pages in JHEP style, references adde

Boson--fermion bound states in two dimensional QCD

We derive the boson--fermion bound state equation in a two dimensional gauge theory in the large--\nc limit. We analyze the properties of this equation and in particular, find that the mass trajectory is linear with respect to the bound state level for the higher mass states.Comment: 5pp, 2 figs (as a separate file), TIT/HEP-23

De Sitter Waves and the Zero Curvature Limit

We show that a particular set of global modes for the massive de Sitter scalar field (the de Sitter waves) allows to manage the group representations and the Fourier transform in the flat (Minkowskian) limit. This is in opposition to the usual acceptance based on a previous result, suggesting the appearance of negative energy in the limit process. This method also confirms that the Euclidean vacuum, in de Sitter spacetime, has to be preferred as far as one wishes to recover ordinary QFT in the flat limit.Comment: 9 pages, latex no figure, to appear in Phys. Rev.